Modulation of alternative splicing contributes to cancer development: focusing on p53 isoforms, p53β and p53γ
نویسندگان
چکیده
منابع مشابه
Expression of TP53 Isoforms p53β or p53γ Enhances Chemosensitivity in TP53null Cell Lines
The carboxy-terminal truncated p53 alternative spliced isoforms, p53β and p53γ, are expressed at disparate levels in cancer and are suggested to influence treatment response and therapy outcome. However, their functional role in cancer remains to be elucidated. We investigated their individual functionality in the p53(null) background of cell lines H1299 and SAOS-2 by stable retroviral transduc...
متن کاملRole of Aberrant Alternative Splicing in Cancer
Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...
متن کاملAlternative Splicing and Cancer
1 Inserm U1052, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Université de Lyon, 69008 Lyon, France 2 Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal 3 Institució Catalana de Recerca i Estudis Avançats (ICREA) and Centre de Regulacio Genomica, Barcelona, Spain 4 Istituto di Genetica Molecolare-Consiglio Nazionale delle Ricerche, Pav...
متن کاملExpression of p53β and Δ133p53 isoforms in different gastric tissues.
This study aims to detect the mRNA of p53β and Δ133p53 isoforms in three gastric carcinoma cell lines and tissues of superficial gastritis, atrophic gastritis, gastric carcinoma, or paracancerous area. Nested reverse transcription PCR was used to detect the mRNA of p53β and Δ133p53 isoforms in tissues of superficial gastritis, chronic atrophic gastritis, gastric cancer cell lines (SGC-7901, MKN...
متن کاملThe plethora of PMCA isoforms: Alternative splicing and differential expression.
In this review the four different genes of the mammalian plasma membrane calcium ATPase (PMCA) and their spliced isoforms are discussed with respect to their tissue distribution, their differences during development and their importance for regulating Ca²⁺ homeostasis under different conditions. This article is part of a Special Issue entitled: 13th European Symposium on Calcium.
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2014
ISSN: 1350-9047,1476-5403
DOI: 10.1038/cdd.2014.99